Organisation/Company: CNRS
Department: Institut des Sciences Moléculaires de Marseille
Research Field: Chemistry, Environmental science
Researcher Profile: First Stage Researcher (R1)
Country: France
Application Deadline: 27 Nov 2024 - 23:59 (UTC)
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Offer Starting Date: 2 Dec 2024
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description The PhD work will be carried out within the Institut des Sciences Moléculaires de Marseille (iSm2), where four research teams work at the interface of synthetic chemistry, biochemistry, biology, and quantum chemistry.
The iSm2, a joint research unit (UMR7313) between the Centre National de la Recherche Scientifique (CNRS), the Ecole Centrale de Marseille (ECM), and Aix-Marseille Université (AMU), is located on the campus of the Faculty of Sciences of St-Jérôme, in Marseille.
The PhD will be conducted under the supervision of Drs. Julien Annibaletto (Associate Professor) and Cyril Bressy (Professor) within the stereO team, which specializes in the development of new synthetic methods in stereoselective catalysis. The team consists of 13 permanent staff members (professors, researchers, and engineers) as well as 11 PhD students and a postdoctoral researcher.
Chiral amines are attractive targets in organic synthesis as useful building blocks to access complex scaffolds, but also due to their ubiquitous presence in numerous biologically relevant molecules. An extensive array of enantioselective methods has been developed to access these chiral amines using organic, organometallic or enzymatic catalysis. One alternative relies on the kinetic resolution of racemic mixture of amines, allowing to selectively convert one enantiomer while the other one ideally remains untouched.
This PhD project aims at tackling the challenge of developing new organocatalyzed processes for the acylative kinetic resolution of amines, with the ambition of reaching high selectivities regardless of the nucleophilicity of the amine derivatives employed. We also aim at exploiting even more challenging diamine derivatives through unusual activation modes, for their kinetic resolution (anti-diamines) as well as their desymmetrization (meso diamines). New classes of organocatalysts will be prepared and evaluated through innovative functionalization methods of (di)amines to achieve these objectives.
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