Organisation/Company: Institut Pasteur
Department: Virology
Research Field: Biological sciences » Biology
Researcher Profile: First Stage Researcher (R1)
Positions: Postdoc Positions
Country: France
Application Deadline: 31 Dec 2024 - 18:00 (Europe/Paris)
Type of Contract: Temporary
Job Status: Full-time
Offer Starting Date: 1 Oct 2024
Is the job funded through the EU Research Framework Programme? Horizon Europe
Is the Job related to staff position within a Research Infrastructure? No
Offer Description Position: Two postdoctoral positions in the FlavImmunity Group to work on two EU HORIZON funded projects.
Reporting to: Giovanna Barba Spaeth, Group leader, Institut Pasteur, Paris, France. Send a single PDF including a cover letter detailing previous research, CV, and names of 3 references to ******.
Contract: These are full-time, fixed-term positions (2-3 years), on Institut Pasteur Paris terms and conditions of employment. The positions are immediately available. Applications will continue to be accepted and considered until the positions are filled.
The Projects:
Yellow4FLAVI: "Deconstructing the protective immunity of yellow fever virus 17D to inform flavivirus vaccine design" aims to identify the determinants of the immunogenicity of the yellow fever 17D vaccine based on the idea that the structure of the 17D viral particle plays a major role in the presentation of epitopes capable of inducing protective immunity. The EU consortium working on Yellow4FLAVI includes 13 laboratories from 7 countries (France, Germany, Italy, Belgium, The Netherlands, Finland, Colombia).
SHIELD: "Molecular strategies against viral entry and glycan shielding" aims to elucidate understudied mechanisms related to viral entry, such as glycosylation and virion dynamics as next-generation therapeutic strategies to target virus families such as Arenaviridae, Paramyxoviridae, and Flaviviridae. Our group will study Flaviviruses such as West Nile virus, Zika, dengue, and yellow fever virus. The EU consortium working on SHIELD includes 10 laboratories from 8 countries (Germany, France, The Netherlands, Portugal, Sweden, Denmark, Poland, Switzerland).
The Research Group: The FlavImmunity group studies the dynamics of viral envelope proteins using a combination of structural (cryo-EM and X-ray crystallography), biochemical (BLI, chromatography), and functional (virus neutralization and fusion assays) approaches. We study new and re-emerging viruses of global public health concern, in particular Flaviviruses such as yellow fever, dengue, Zika, or West Nile.
We value diversity, inclusion, sustainability, gender, and life/work balance.
The Institute: The Institut Pasteur (IP) is an international life science research institute located in the heart of Paris, France. Founded in 1888 to honor the success of Louis Pasteur in developing a human vaccine against rabies, the Institut Pasteur supports a planetary vision of scientific research as stated by the words of Louis Pasteur: "Science knows no country, because knowledge belongs to humanity, and is the torch which illuminates the world."
Where to apply E-mail: ******
Requirements Research Field: Biological sciences » Biology
Education Level: PhD or equivalent
Skills/Qualifications:
PhD in relevant discipline (Virology, Immunology, Molecular Biology, Biochemistry)
Good knowledge in molecular and/or structural biology
Technical expertise in standard biochemistry techniques
Experience with CryoEM data processing will be considered an advantage
Track record of writing papers and data presentation at scientific meetings
Strong drive for challenging projects, initiative, and teamwork
Specific Requirements:
You will be responsible for carrying out virological assays, antigen design, and structural studies on whole virus using cryoEM. You will use cryoEM and X-ray crystallography to screen binding of inhibitors to the flavivirus envelope protein. You will conduct your own project and interact tightly with the other researchers of the Yellow4FLAVI or SHIELD consortia. You may guide PhD and master students in their research.
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