Principal Investigator – Computational Cancer Genomics

Principal Investigator – Computational Cancer Genomics We are seeking a highly skilled and motivated Principal Investigator with expertise in computational cancer genomics, specialising in whole genome sequencing (WGS) and the development and implementation of best practices informatic pipelines. The ideal candidate will have extensive experience in utilising cutting-edge sequencing platforms to advance our understanding of cancer biology and facilitate the translation of genomic discoveries into clinical applications.
The selected candidate will Lead a dynamic research team focused on computational cancer genomics, providing scientific direction and mentoring junior staff;
Design and execute experiments utilising whole genome sequencing technologies to study cancer biology, including tumour evolution, clonal dynamics, and genomic alterations;
Develop and optimise bioinformatics pipelines for the analysis of WGS data, ensuring robust and reproducible results;
Implement best practices for data quality control, variant calling, and annotation to identify driver mutations, structural variants, and other genomic aberrations associated with cancer;
Collaborate with clinical partners to integrate genomic findings into precision medicine approaches for cancer diagnosis, prognosis, and treatment;
Stay abreast of advancements in third generation sequencing platforms and emerging technologies, evaluating their potential impact on cancer genomics research;
Publish research findings in high-impact peer-reviewed journals and present results at scientific conferences;
Contribute to grant writing and fundraising efforts to support ongoing research projects and secure additional funding for future initiatives.
Requirements Research Field: Biological sciences; Biology; Computer science; Informatics
Education Level: PhD or equivalent
Years of Research Experience: More than 10
English level: Excellent
Skills/Qualifications Ph.D. or equivalent degree in genetics, genomics, bioinformatics, or a related field.
Specific Requirements Proven track record of research excellence in computational cancer genomics (at least 7 co-authored high impact factor publications), with a focus on whole genome sequencing analysis;
Expertise in bioinformatics analysis of cancer WGS data, including proficiency with programming languages (e.g. Python and R) and best practice bioinformatic pipelines including GATK, SAMtools, BWA, Manta, GRIDSS, IGV;
Experience (hands-on) with third-generation sequencing platforms (e.g., PacBio, Oxford Nanopore) and familiarity with long-read sequencing data analysis techniques;
Experience working with High-Performance Computing cluster environments (e.g. SLURM);
Expertise in bioinformatics analysis of RNAseq and single cell RNAseq data;
Experience in controlled-access data management;
Experience in developing and managing multicentre cancer genomics studies;
Strong communication and leadership skills, with the ability to work effectively in a collaborative research environment;
Demonstrated ability to secure research funding through grants or other mechanisms;
Prior experience managing research projects and supervising research staff and students is preferred.
Key Skills Leadership;
Problem solving;
Flexibility;
Attention to Detail;
Communication;
Organisation;
Initiative.
- Competitive fellowship commensurate with skills, qualifications and experience.
- Full immersion into a research excellence ecosystem with highly motivated researchers, supported by state-of-the-art technology and continuous development opportunities.
Maximum allowable duration of the contract including the respective renewals.
Eligibility criteria National, Foreign or Stateless candidate(s) who hold a Ph.D. or equivalent degree in genetics, genomics, bioinformatics, or a related field and professional curriculum that reveals a profile appropriate to the activity to be developed.
Selection process All CVs and motivation letters will be reviewed by the selection committee. Reference letters will be requested from shortlisted candidates, and those candidates deemed particularly well suited for the position will be invited for an interview.
Evaluation Committee members John P. Neoptolemos (Director of Clinical Research)
Peter Bailey (Director of Translational Research)
Craig Nourse (Manager of Advanced Platforms)
Application materials Candidates must provide A completed application form: Call Ref. "PI-CCG_BCPCC"
A letter of motivation (max. 2 pages), highlighting your suitability for the role, salary expectations and notice period.
CV (max. 2 pages)
Names and contact information for at least 2 references. If you do not wish that we contact current or past employers, please state so and why in your letter of motivation.
How to apply Candidates must complete the standard application form and submit a single annexed PDF document containing the application materials stated in the call;
The call reference will be asked and not having may invalidate your submission;
This call reference is PI-CCG_BCPCC.
Applications are also accepted in paper, sent or handed to:
Notification of results All candidates will receive a receipt of acknowledgment within 7-10 business days. The highest scoring candidate will be notified by email or telephone. All other candidates will be notified solely by email of the outcome of the recruitment process.
After being notified, candidates will have 10 working days to present a claim for redress by email (******). If no claim is received by the Champalimaud Foundation, the Evaluation Committee's decision will become definitive.
About Us Research is at the heart of the Champalimaud Centre for the Unknown, a modern research and clinical facility situated on the waterfront in Lisbon, Portugal. The goal of Champalimaud Research (CR) is to perform world-leading fundamental and translational research. Current research work is focused on the fields of neuroscience, physiology, and cancer. Champalimaud Research comprises a team of over 400 scientists from around the world. English is the official language of the Centre. Lisbon's sunny Atlantic Mediterranean climate, vibrant culture, and high quality of life make this a great place to live and work.
Relevant Institutional Information In line with our community guidelines and Equality, Diversity and Inclusion policy and Gender Equality Plan, no candidate may be privileged, favored, prejudiced or deprived of any right or excluded from any duty on the basis of age, sex, gender identity, sexual orientation, race/ethnicity, disability, chronic illness, language, nationality, territory of origin, family status (marital, pregnancy and maternity, having or not having dependents), socioeconomic situation, education, religion, political or ideological beliefs, trade union membership, or on any other grounds which are irrelevant to decision-making.
The present call has the sole purpose of filling the indicated research position. This call may be canceled at any time on or before the jury's evaluation of all eligible candidates and the recruitment process shall be concluded on the day of the full execution of the contract between the Champalimaud Foundation and the selected candidate.

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