Organisation/Company: LaTIM - Brest
Research Field: Medical sciences » Cancer research
Positions: Postdoc Positions
Country: France
Application Deadline: 31 Dec 2024 - 12:00 (Europe/Paris)
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Offer Starting Date: 1 Jan 2024
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description Context and objectives:
External radiotherapy is one of the main treatments against cancer, alongside surgery and chemotherapy, and it concerns 60% to 70% of patient care in oncology. This treatment involves delivering the maximum possible dose to the tumour while minimizing the dose to organs at risk. Recently, rotational beam-delivery techniques such as volumetric modulated arc therapy (VMAT) have gained popularity, which refers to radiotherapy treatments where the treatment beam is continuously on while the gantry rotates around the patient. Current VMAT treatments utilize a coplanar beam trajectory with a fixed couch angle. Treatment plans using non-coplanar beam angles, also known as 4p radiotherapy, can significantly improve radiation dose conformality and spare critical organs. Non-coplanar beams are achieved by moving the couch (position and rotation) during the gantry trajectory. However, the implementation of this treatment strategy has faced challenges such as inaccurate solution space modeling, limited automated beam selection methods, and lack of efficient beam sequencing programs.
We have recently developed a non-coplanar beam inverse planning approach to optimize such treatment. The aim of the postdoc is to combine all necessary codes developed by LaTIM with the latest version of Eclipse (Varian Medical System) to create a non-coplanar treatment planning framework for processing and evaluating clinical data. Additionally, new non-coplanar trajectories and collimation optimization will be explored and implemented. The next stage will involve evaluating each non-coplanar strategy through clinical data in various contexts, such as extreme dose escalation in glioblastoma or stereotactic radiotherapy in prostate cancer, to determine if non-coplanar beams can lead to substantial improvements in dosimetry and toxicity, as well as the potential for new therapeutic strategies.
This project is part of a partnership with VARIAN Medical System and the radiotherapy department of Brest University Hospital, and LaTIM (INSERM). The position will be based in Brest, France, at the LaTIM laboratory (INSERM UMR1101). The starting date is planned for early 2024 but may be flexible depending on the candidate's availability. The initial contract is for one year, with the possibility of renewal for an additional year.
Where to apply E-mail: ******
Requirements Research Field: Medical sciences » Cancer research
Education Level: PhD or equivalent
Research Field: Physics » Other
Education Level: PhD or equivalent
Research Field: Other
Education Level: PhD or equivalent
Skills/Qualifications:
Education: The candidate must have a PhD degree in medical physics.
Scientific interests: Dosimetry, non-coplanar beam, external radiotherapy, inverse planning.
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