Organisation/Company: Nantes Université
Research Field: Biological sciences » Biology
Researcher Profile: First Stage Researcher (R1), Recognised Researcher (R2)
Positions: Postdoc Positions
Country: France
Application Deadline: 30 Nov 2024 - 23:00 (Europe/Paris)
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 38h
Offer Starting Date: 1 Feb 2025
Is the job funded through the EU Research Framework Programme? Other EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description The proposed position is part of the ANR-funded international project "Novel strategies for Osteoarthritis treatment based on innate LYMPhoid Cells modulation - OLYMPiC2024" led by Marie-Astrid BOUTET. A junior postdoctoral position is funded by this international program to participate in the characterization of the heterogeneity of innate lymphoid cells (ILC) in synovial tissues from patients with osteoarthritis (OA) and in the development of novel therapeutic approaches for this disease. This project is in collaboration with Charité – Universitätsmedizin Berlin.
Main Activities Contribute to the establishment of two novel cohorts of human and canine OA patients, and to the collection, storage and histological characterization of the samples collected at Nantes University Hospital and ONIRIS veterinary school.
Analyse the heterogeneity of ILC in public datasets and single-cell RNA sequencing data already obtained in the lab.
Characterize the heterogeneity of ILC in human and canine tissue and blood samples using flow cytometry, immunofluorescence, ELISA, and high-throughput approaches, including single-cell RNA sequencing and spatial transcriptomic.
Participate to the analysis of metagenomic data from OA canine feces samples.
Participate to the development of mouse models of OA that will be performed in Berlin in different full and conditional knock-out strains, and to their histological characterization.
Contribute to the training and supervision of master and PhD students.
Present the results of the project in lab meetings, national and international congresses.
Where to Apply E-mail: ******
Requirements Research Field: Biological sciences » Biology
Education Level: PhD or equivalent
Skills/Qualifications General, theoretical or disciplinary knowledge:
Good knowledge in lymphocyte biology,
Inflammatory joint diseases,
High-throughput analyses approaches.
Operational skills:
Technical expertise in cellular and molecular biology, histology and immunofluorescence, flow cytometry, ELISA (required),
Experience in managing biocollection of human tissues (required),
Experience in bioinformatic analyses (R or Python), including single-RNA sequencing (required), spatial transcriptomic (optional) and metagenomic analyses (optional),
Experience in animal experimentation (required), including the induction of mouse models of joint diseases (optional),
Excellent oral and written English communication (required),
Previous experiences of student supervision or teaching (required).
Teamwork and interpersonal skills.
Languages: ENGLISH Level Excellent
Languages: FRENCH Level Basic
Years of Research Experience: 1 - 4
Internal Application form(s) needed
Salary: To be defined based on experience, between 2500 € to 2900 € by month
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