Organisation/Company: Universite de MontpellierDepartment: Human ResourcesResearch Field: Biological sciences » BiologyResearcher Profile: Recognised Researcher (R2)Positions: PhD PositionsCountry: FranceApplication Deadline: 22 Dec 2024 - 23:59 (Europe/Paris)Type of Contract: TemporaryJob Status: Full-timeIs the job funded through the EU Research Framework Programme? Horizon EuropeReference Number: 2025-R0031Is the Job related to staff position within a Research Infrastructure? NoOffer DescriptionWork Environment:The researcher will be based at the MIVEGEC research unit. S/he will have access to dedicated biosafety 2 infrastructure for cellular biology and microbiology, as well as to molecular biology and protein biology laboratories. S/he will have access to in-site computational facilities at the IRD bioinformatic cluster. Full time on site, except for missions/projects (in Montpellier, France and abroad). Office hours which may also include exceptional hours due to the nature of experimental design (weekends, public holidays).Main Mission:To study the evolutionary mechanisms that generate proteomic diversity in viruses that cause chronic infections, and their impact on viral fitness in terms of quality, duration and intensity of the immune response, productivity and potential for transmission of infection.Activities:Bioinformatics analysis, including comparative analysis of transcriptomic data (RNA-Seq), proteomic data (label-free proteomics), cytometry, real-time cell growth (xcelligence).Advanced statistical analysis of data, interpretation of results, report generation.Evolutionary analyses.If necessary, development of methodologies.Regular reading of articles and writing of scientific articles.Contribution to the scientific life of the team.Training and supervision of students.Contribute to the training and technical supervision of other users of bioinformatics tools.Participation in international conferences.Contribution to the design and monitoring of selection and biological competition experiments.Molecular and cellular biology in confined L2 environments (genes, oncogenes or viral genomes), protein biochemistry.Conception, design and execution of experiments, interpretation of results, generation of reports.Where to ApplyE-mail: ****** Field: Biological sciences » BiologyEducation Level: PhD or equivalentSkills/Qualifications:Ability to work in a team and interact with experts in bioinformatics and experimental biology.Bioinformatics: analysis of transcriptomic and proteomic data; advanced use of R and a script programming language; implementation of robust and repeatable bioinformatics pipelines. Sequence and plasmid management.Evolutionary biology: familiarity with complex concepts in evolutionary biology (biological information transfer, codon usage, selection/mutation, multi-level selection, noise) as well as in molecular and cellular biology.Experimental biology: (rt)-qPCR; western blot; quantification of DNA, RNA and proteins; sample preparation for NGS and proteomics; microbiology techniques for molecular biology; cloning, transformation, plasmid prep; cell culture in biosafety level 2; transfection, cytometry, xcelligence.Advanced statistical analysis skills.Perfect command of English (reading, writing and speaking).Ability to synthesize and write in English, and to work autonomously.Specific Requirements:PhD required in Molecular and cellular biology.Additional InformationWork Location(s)Number of offers available: 1Company/Institute: Maladies Infectieuses et Vecteurs : Ecologie Génétique Evolution et Contrôle (MIVEGEC)Country: FranceCity: Montpellier
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