Research Technician at the van Gisbergen / Tissue Immunity LabThe selected candidate willThe Research Technician will work on a project in the research group of Dr Klaas van Gisbergen in the Tissue Immunity Lab at the Champalimaud Foundation. He/she will be part of a larger research team in a collaborative initiative between the labs of Dr Joke den Haan at Amsterdam UMC, Dr Sonja Buschow at Rotterdam UMC and Dr van Gisbergen at the Champalimaud Foundation. The Research Technician will be working in close collaboration with co-workers in the lab and at the other institutes. His/her tasks will include lab management and the planning and execution of experiments.The projectThe aim of the project is to understand how T cells can be optimally geared to fight solid tumors using vaccination strategies. More specifically, we will explore how vaccination approaches can induce resident memory T cells to improve immune defense against cancer. We will focus on how the development of resident memory T cells can be instructed in the liver to provide local protection against hepatocellular carcinoma. The research will be performed using advanced techniques in flow cytometry and transcriptional profiling and using unique tools developed in house to visualize and manipulate resident memory T cells.The labThe lab of Tissue Immunity focuses on the development of memory T cells in infection and tumor settings and the transcriptional and molecular pathways underlying T cell differentiation. The eventual goal is to improve the exploit of T cells for the purpose of cancer immunotherapy. The lab is embedded in the department of Cancer and Physiology at the Champalimaud Foundation that provides a lively, internationally oriented, scientific environment with excellent facilities. The research is strongly multidisciplinary and includes neuroscience, tumor biology and tumor immunology making use of state-of-the-art techniques in in vivo models, molecular biology, flow cytometry and fluorescence microscopy.Department: Cancer and Physiology, Tissue Immunity (van Gisbergen) LabWe are looking for an enthusiastic colleague with a BSc/MSc in Biology / Biomedical Sciences, who is highly motivated and has a proven interest in immunology and oncology. The candidate is expected to take initiative and perform well in a team and preferably has hands-on experience with animal experimentation, in vivo tumor models and/or multi-color flow cytometry.Required Education LevelBSc/MSc in Biomedical Sciences or related areas.RequirementsResearch Field: Biological sciences » OtherEducation Level: Bachelor/Master Degree or equivalentSpecific RequirementsMolecular techniques, transcriptional profiling and bioinformatics analysis.Excellent level of English.Competitive remuneration package commensurate with skills, qualifications and experience.Full immersion into a research excellence ecosystem with highly motivated researchers, supported by state-of-the-art technology and continuous development opportunities.Maximum allowable duration of the contract including the respective renewals OR Initial duration24 months with possibility of renewal.Eligibility criteriaNational, Foreign or Stateless candidate(s) who hold a BSc/MSc degree in Biomedical Research Areas or other related scientific areas and a scientific and professional curriculum that reveals a profile appropriate to the activity to be developed.Selection processCandidates will be screened to determine eligibility based on minimum qualifications listed in call. Candidates meeting minimum requirements will be scored according to the required application materials: CV 70% weighting, motivation letter 20%, interview 10% (in case of a tie).Application materialsCV and letter of motivation indicating 2 references (one single pdf document). Proof of qualifications (certificates) may be required at a later date for the formalisation of the contract agreement. Degrees obtained abroad may need to be formally recognised in Portugal.How to applyCandidates must complete the standard application form and submit a single annexed PDF document containing the application materials stated in the call. The call reference will be asked and not having may invalidate your submission. This call reference is: "RT KWF Van Gisbergen Apr2024"Notification of resultsAll candidates will receive a receipt of acknowledgment within 7-10 business days. The highest scoring candidate will be notified by email or telephone. All other candidates will be notified solely by email of the final outcome of the recruitment process.About UsResearch is at the heart of the Champalimaud Centre for the Unknown, a modern research and clinical facility situated on the waterfront in Lisbon, Portugal. The goal of Champalimaud Research (CR) is to perform world-leading fundamental and translational research. Current research work is focused on the fields of neuroscience, physiology and cancer. Champalimaud Research comprises a team of over 400 scientists from around the world. English is the official language of the Centre. Lisbon's sunny Atlantic Mediterranean climate, vibrant culture and high quality of life make this a great place to live and work.
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