Organisation/Company CNRS Department Intégrité du Génome et Cancers Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Country France Application Deadline 23 Dec 2024 - 00:00 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 2 Dec 2024 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description Postdoctoral Position to Study the Contribution of R-loop Structures to Cancer Vulnerability and Therapeutic Response, within the Genome Integrity and Cancers Unit (UMR 9019, [https://www.gustaveroussy.fr/fr/umr-9019 ]) at the Gustave Roussy Institute, located in the south of Paris.
Laboratory Interests: R-loops, three-stranded nucleic acid structures composed of an RNA-DNA hybrid and a displaced single-stranded DNA, play key roles in genome dynamics. They are formed co-transcriptionally over 5 to 10% of the mammalian genome, and are involved in various biological processes such as immunoglobulin class switching, mitochondrial DNA replication, gene expression regulation, transcription termination, and telomere stability. However, unscheduled R-loop formation is a major source of endogenous replication stress and genomic instability, causing transcription-replication conflicts (TRC) and DNA damage. Dysregulation of R-loop homeostasis is a major hallmark of cancer cells, making R-loops relevant targets for cancer treatment. The postdoc's mission is to study how R-loops contribute to genome instability and influence the therapeutic response in certain types of cancer.
Our group has highlighted a vulnerability related to R-loop formation, specific to cancer cells with defects in the FANC/BRCA molecular pathway, a DNA repair pathway inactivated in certain tumors of the upper aerodigestive tract and gynecological cancers. The project aims to determine the dynamics and mechanisms of R-loop formation in these cancers, as well as to develop therapeutic approaches targeting these structures.
The "Genome Integrity and Cancer" research unit brings together leading scientists in the fields of DNA replication, repair, and mechanisms of genetic and epigenetic stability. It benefits from a dynamic and multidisciplinary environment in collaboration with the translational and clinical research teams at Gustave Roussy. The Gustave Roussy Institute, Europe's leading cancer center, offers access to state-of-the-art facilities, including cellular and molecular imaging, genomics, bioinformatics, and animal experimentation. The funding is offered for a period of 18 months. The candidate must have a strong publication record to also be able to apply for independent funding.
Interested in the position? Please send your application in a single PDF file to the address indicated in the offer. The application should include a cover letter describing your main contributions and research interests, your CV, and contact details for 2 or 3 references. The expected start date is December 2024, and applications will be reviewed until a candidate is selected.
The candidate must hold a PhD and have strong skills in cellular and molecular biology, as well as in genome-wide approaches. Experience in animal experimentation would be an asset. We invite highly motivated and dynamic individuals, capable of working independently while having a good team spirit, to apply. Professional experience in the field of DNA replication or repair would be ideal.
Additional comments
The candidate must be proficient in English; a good knowledge of French is desirable.
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