Organisation/Company: CNRS
Department: Polymères, biopolymères, surfaces
Research Field: Chemistry » Physical chemistry, Physics » Chemical physics, Physics » Biophysics
Researcher Profile: Recognised Researcher (R2)
Country: France
Application Deadline: 16 Dec 2024 - 00:00 (UTC)
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Offer Starting Date: 3 Feb 2025
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description Cancer remains a global health crisis, responsible for approximately 10 million deaths annually. Conventional treatments like chemotherapy and radiotherapy have limitations, driving the search for new approaches such as immunotherapy, which boosts the immune system to target tumor cells. A highly motivated candidate is sought for a postdoctoral position to join our cutting-edge research team focused on developing advanced biomaterials for cancer immunotherapy. This project aims to harness the potential of biomaterials to improve the delivery and efficacy of T cells in solid tumors, significantly impacting human health and expediting clinical translation.
Key Responsibilities:
Developing and optimizing biomaterials, tuning their properties, and creating new technologies for their transdermal delivery.
Functionalizing biomaterials with specific antibodies in in-vitro studies.
Controlling the release of immunostimulatory factors.
Evaluating the potential of these biomaterials to enhance T-cell viability and function in solid tumors.
Conducting preclinical evaluations in cancer models and exploring potential synergistic effects with other therapies.
The candidate will join an interdisciplinary group that incorporates expertise in polymer chemistry, design of hydrogel systems, nanotechnology, microfabrication, tissue engineering, drug delivery, and immunotherapy.
The postdoctoral researcher will be employed by CNRS, Europe's largest fundamental science agency, and conduct research under Dr. Sidi A. Bencherif at the Polymers, Biopolymers Surfaces (PBS) Laboratory (UMR CNRS 6270), located at University Rouen Normandy. PBS aims to develop innovative high-performance polymers through macromolecular chemistry, employing physical, physico-chemical, and biological approaches, and evaluating their functions in diverse environments, including biological systems.
The position is located in a sector under the protection of scientific and technical potential (PPST), and therefore requires, in accordance with the regulations, that your arrival is authorized by the competent authority of the MESR.
Qualifications:
Ph.D. in immunoengineering, immuno-oncology, cancer immunotherapy, or related fields.
Expertise in DC/T cell culture and proficiency in a wide range of molecular and cellular biology techniques, including qRT-PCR, western blotting, ELISA, and flow cytometry.
Expertise in biomaterials and/or polymer chemistry.
Solid understanding of biofunctionalization.
Proficiency in isolating, culturing, handling, and characterizing human primary DC/T cells and performing immune cell-based assays.
Experience with animal models for immunotherapy testing.
Strong communication, collaboration, and self-motivation skills.
A track record of publications in leading peer-reviewed journals.
Additional comments: Candidates should apply through the CNRS job portal by submitting their applications, which must include a curriculum vitae (with a complete list of publications), a cover letter detailing research experience, expectations for the position, and future career goals, along with contact information for three references. Join our team to contribute to groundbreaking research in biomaterials and cancer immunotherapy, making a substantial impact on society!
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