Organisation/Company: CNRS
Department: Institut de Recherche en Infectiologie de Montpellier
Research Field: Neurosciences, Biological sciences
Researcher Profile: First Stage Researcher (R1)
Country: France
Application Deadline: 28 Nov 2024 - 23:59 (UTC)
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Offer Starting Date: 15 Jan 2025
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description We are looking for a talented and motivated scientist to join our team "Membrane Dynamics & Viruses" (MDV) led by Dr. Raphael Gaudin, part of the IRIM institute located on the CNRS campus of Montpellier, France. Our team has expertise in cellular neurobiology and virus infections. We are now looking for a dynamic candidate to integrate our team, bringing his/her expertise in neurobiology to lead a very ambitious project at the crossroad of several disciplines and at the frontier of current knowledge.
The project includes culture of 2D stem cell derived neurons, 3D cerebral organoids and post-mortem human brain slices and electrophysiological measurement using microelectrode arrays (MEA) to monitor functional neuronal activity and synaptic homeostasis in physiological conditions and upon viral infection. This international project will have a particular focus on neurodevelopmental perturbations associated with viral infections. The project is tightly bound to clinicians and bioinformaticians to ensure that all expertise needed synergizes to achieve our goals. Funding to hire a young post-doc for 2 years is available, with the aim to extend it, in order to complete the project with the most successful outcome.
Responsibilities Stem cell culture, differentiation, and culture of neural stem cells and organoids.
Human tissue explant culture.
Electrical activity recording on microelectrode arrays (MEA) and analysis.
Immunostaining preparation and confocal microscopy imaging.
Classical molecular and cell biology techniques, including RT-qPCR, western blot, flow cytometry, and virus production.
The proposed project will take place in the beautiful coastal city of Montpellier, in the south of France. The IRIM institute is located on the CNRS campus, gathering vibrant research labs specialized in cell biology, genetics, infectiology, neurobiology, ecology, and chemistry. The campus hosts high-end microscopy, flow cytometry, and biosafety level 2 and 3 facilities. The candidate will benefit from a very dynamic workplace and a stimulating international scientific and social environment.
Our international team is composed of 15 members from diverse origins, showing interdisciplinary skills and developing a wide range of advanced biological knowledge in cell biology, virology, and neurobiology. All lab interactions are in English, and include weekly lab meetings, internal and external seminars, and institute and lab retreats. The team benefits from a friendly and supportive atmosphere, with the aim to achieve our goals in a publication-oriented, efficient, and thorough manner. Promoting individuals' careers through experimental and conceptual mentoring is also a collective endeavor.
Qualifications We are looking for a candidate with expertise in stem cell culture and neurobiology. Knowledge in electrophysiology, microscopy, or organoids is a plus. Good written and oral skills in English are required. French is not a prerequisite.
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