Organisation/Company: University Paris Cité - UMR CNRS 7591
Department: Chemistry
Research Field: Chemistry » Physical chemistry, Chemistry » Analytical chemistry
Researcher Profile: First Stage Researcher (R1)
Positions: Postdoc Positions
Country: France
Application Deadline: 28 Feb 2025 - 00:00 (Europe/Paris)
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Offer Starting Date: 3 Mar 2025
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description Measuring the shot noise of redox events: a novel sensing approach for nano-bio-electrochemistry.
The measurement of low faradaic currents associated with the detection of single molecules remains a major instrumental challenge in nano-electrochemistry. Beyond this sensitivity limit, the nature of the measurement itself changes as soon as a "small" number of molecules are involved: deterministic signals give way to the detection of random phenomena. These are manifested in the form of "noise" superimposed on the mean signal, which becomes more important as the number of molecules being probed decreases. In this case, information is not obtained from the time-averaged signal but rather from a statistical analysis of stochastic events. Therefore, the design of electrochemical sensors on the nanoscale must be accompanied by the development of new measurement schemes that allow for the recording and analysis of the stochastic noise component of electrochemical signals. The objective of this project is to explore this new path for nanoscale/single molecule conformational DNA electrochemical biosensors. The research in LEM will focus on the study of the redox-cycling noise, generated by redox DNA chains attached by their extremity and confined in electrochemical nanogaps produced by Electrochemical-Atomic Force Microscopy (AFM-SECM). The redox-cycling noise will be acquired and analyzed with the help of a molecular dynamics software, capable of reproducing the Brownian motion of DNA chains and associated electron transfer events, developed by the physicist partner of this project (LAAS). The aim is to understand the underlying physical-chemistry of the redox-noise and determine its potential as an observable for DNA nanodetection.
Where to apply E-mail: ******
Requirements Research Field: Chemistry » Physical chemistry
Education Level: PhD or equivalent
Skills/Qualifications: The candidate must have a Ph.D. in chemistry, physics or biophysics. She/he should be a skilled experimentalist. Some experience in local probe microscopies (AFM, etc.) and/or in electrochemistry would be appreciated.
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