Department of Developmental and Stem Cell Biology
Organisation/Company: Institut Pasteur
Research Field: Biological sciences » Biology
Researcher Profile: First Stage Researcher (R1), Recognised Researcher (R2)
Positions: PhD Positions
Country: France
Application Deadline: 10 Jan 2025 - 00:00 (Europe/Paris)
Type of Contract: Temporary
Job Status: Full-time
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description The heart functions in two parallel but asymmetric circuits, where the right and left ventricles drive the pulmonary and systemic circulations, respectively. In heterotaxy syndrome, abnormal left-right patterning of the embryo leads to a spectrum of severe structural heart defects. Although the molecular cascade breaking the bilateral symmetry of the early embryo has been well characterised, the mechanisms through which asymmetry is sensed by organ-specific precursor cells to control organogenesis remain poorly understood. The Meilhac lab uses mouse models to elucidate basic mechanisms of asymmetric heart morphogenesis, uncover novel genetic players, and explore their relevance to congenital heart defects in patients.
Previous work in the lab has characterised mouse models of heterotaxy and generated a large transcriptomic dataset to screen for novel asymmetric factors. A challenge is to understand their function at specific asymmetric steps of heart morphogenesis. This project will exploit interdisciplinary expertise at the forefront of developmental biology, computational science, and pediatric cardiology. Using cutting-edge technologies in omics, mouse genetics, and quantitative 3D imaging, the project will provide novel insights into basic morphogenesis mechanisms while deciphering pathological processes in the heart, potentially relevant to other asymmetric visceral organs.
Our lab is located at the Institut Imagine , within the hospital Necker-Enfant Malades, and is part of the Dept of Developmental and Stem Cell Biology of the Institut Pasteur, which offers a vibrant multidisciplinary and international research environment with state-of-the-art technological platforms in downtown Paris.
The postdoctoral position is funded for 3 years by the FRM and is open ASAP.
Where to apply E-mail: ******
Requirements Research Field: Biological sciences » Biology
Education Level: PhD or equivalent
Skills/Qualifications After obtaining a PhD in Life Sciences, you should have a strong interest in developmental biology. Your previous research experience should be solid in molecular biology or genetics. You should value animal models, work with rigor and creativity, and enjoy teamwork.
Specific Requirements To apply, please send a cover letter, CV, and contact details of 3 references.
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