Organisation/Company: CNRS
Department: Institut Cochin
Research Field: Pharmacological sciences
Researcher Profile: First Stage Researcher (R1)
Country: France
Application Deadline: 2 Dec 2024 - 00:00 (UTC)
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Offer Starting Date: 1 Feb 2025
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description Role of metabolic dysregulation in the pathophysiology and progression of neurodegenerative diseases:
An increasing body of evidence points to the existence of a link between metabolic dysfunction and neurodegenerative diseases (ND), but the molecular mechanisms are poorly known. We are seeking a highly motivated and talented Postdoctoral Researcher to join this FRM-funded multidisciplinary project to uncover the complex interaction between metabolic function and ND pathophysiology, in vitro and in vivo (PI: Dr. Erika Cecon).
Responsibilities: Characterize the metabolic function in transgenic mouse models of ND
Investigate the impact of metabolic dysfunction on the development and progression of ND
Investigate the underlying molecular and cellular mechanisms governing the link between players involved in ND and metabolic (dys)function
The main techniques to be performed by the researcher comprise: cell culture and cell signaling, western blot, in vivo metabolic profiling, mitochondrial function analysis, immuno-histology/cytology/ confocal microscopy.
Team Description: The team "Functional pharmacology and pathophysiology of membrane receptors" is part of the Institute Cochin located in the center of Paris, 22 rue Méchain – 75014 Paris, France. Team leader: Dr. Ralf JOCKERS. The team is composed of approx. 15 collaborators and has a specific interest in identifying new therapeutic approaches for metabolic and neurodegenerative diseases. We are developing original Nanoluciferase complementation, BRET and TR-FRET cellular assays combined with photo-pharmacology and knockout and knockin mouse models. Our work is highly interdisciplinary, gathering molecular pharmacologists, biochemists, physiologists, and chemists coming from all over the world.
Minimum Requirements: Experience in mammalian cell culture, cell biology
Experience in analysis of protein expression by western-blot and by immuno-fluorescence analysis of cells and tissues in confocal microscopy
Experience in animal experimentation
Excellent communication skills in English, orally and written
Good organization and scientific rigor skills
Curiosity and motivation for scientific projects
Ability to solve problems
Team-oriented personality
Strong analytical skills and experience with data analysis tools
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