Organisation/Company: Univ. Grenoble Alpes
Department: Chimie Biologie Santé
Research Field: Chemistry » Organic chemistry
Researcher Profile: Established Researcher (R3)
Country: France
Application Deadline: 10 Dec 2024 - 23:59 (Europe/Paris)
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Offer Starting Date: 1 Feb 2024
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description Context: Tyrosinase is the key enzyme involved in the biosynthesis of melanin, pigment found in the skin and eyes that are the cause of various diseases. For discovering efficient tyrosinase inhibitors, our strategy is to target the tyrosinase dicopper active site which plays a central role in tyrosinase activity.
Methodology:
The design of these new inhibitors will be inspired by the integration of knowledge of the tyrosinase enzyme or biomimetic model structures and by the use of the fundamental recognition properties of inorganic chemistry. Substrate mimics or known inhibitors combined with groups able to bind selectively to the active site of the dicopper should yield safe and potent compounds according to a strategy validated by our recent results.
Although the project requires an organic synthesis background, the question of how selected inhibitors (or potential inhibitors) bind/interact with the active site of the enzyme using computational approaches is also part of the project aimed at understanding inhibition mechanisms and streamlining the design of improved inhibitors.
In addition, the candidate will interact with a well-established network of external partners to evaluate the activity of the synthesized molecules.
Where to apply E-mail: ******
Requirements Research Field: Chemistry » Organic chemistry
Education Level: PhD or equivalent
Skills/Qualifications: The candidate should be highly motivated, to work in a multidisciplinary project and to interact with external partners. The project requires a solid experience in organic syntheses, as well as an interest for bioinorganic chemistry. A background in molecular modeling is an advantage.
Specific Requirements:
Application: To apply, please send a CV (max. one page), PhD degree less than 3 years ago, covering letter and details for potential referees to the contacts.
Contacts/Location Du MOULINET D'HARDEMARE Amaury/ BELLE Catherine
DCM, Equipe CIRe, 301 rue de la Chimie, Bat C, CS 40700, 38058 GRENOBLE cedex 9, France,
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