.Clinical Laboratory TechnicianLocalização: Champalimaud Centre for The UnknownEntidade Empregadora: Champalimaud FoundationRegime: Tempo InteiroPosição: TécnicoInício da Candidatura: 17 Jul. 2024The Champalimaud Foundation, a private, non-profit research institution in Lisbon, Portugal, is looking for a Clinical Laboratory Technician to join our team at the Champalimaud Experimental Clinical Research Programme, specifically the Immunotherapy / Immunosurgery Lab.We are looking to expand efforts in the GMP production of cell products. The successful applicant is expected to be a pivotal co-worker in a team dedicated to developing and improving immune cell-based therapies for patients with cancer with a focus on GMP compliant production of cell products including gene-modified immune cells.The selected candidate will assume the duties/responsibilities below:Lab management and organisation with an excellent team and collaborative spirit within the institution and with our international partners; Close interaction with clinical colleagues and within immunotherapeutic programmes; Analysis and interpretation of immune responses; Procurement of clinical samples; Procurement of cellular products for (non-vector and vector-based) therapy; Execution of processes in immune-histology and cellular analysis; In vitro tissue culture; Advanced flow cytometric analyses and QC documentation; Molecular biology skills.Required Education Level: Masters degree.Minimum qualifications:Very good knowledge in molecular techniques, cloning, excellent knowledge in flow cytometry, T-cell sorting and gauging immune effector functions.Team spirit and will to collaborate within the Foundation and with our partner institutions with the possibility to travel for clinical, international projects.Essential skills:Strong knowledge in human T-cell and B-cell biology and immunology.Documented and well advanced practical and theoretical knowledge in (human) T-cell immunology, T-cell receptor, B-cell receptor structure / analysis and biology, DNA cloning and (vector, e.G. lentiviral) guided transfer of genetic material into recipient cells.Experience working with lentiviral (LV) and non-LV based gene transfer.Excellent skills in immuno-histology and in situ analysis of B- and T- cell responses in malignant diseases.Required Languages: Fluency in English and excellent communication skills (written and verbal) in English.Benefits:Competitive remuneration package commensurate with skills, qualifications and experience.Full immersion into a research excellence ecosystem with highly motivated researchers, supported by state-of-the-art technology and continuous development opportunities.Initial duration: 12 months with possibility of renewal; the contract is first provided for three months and then prolonged
