2 Postdoctoral Fellows at Tissue Immunity Lab
Localização: Champalimaud Centre for The Unknown
Entidade Empregadora: Champalimaud Foundation
Regime: Tempo Inteiro
Posição: Pós-Doutoramento
Início da Candidatura: 11 Jul. 2024
Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud), a private, non-profit research institution in Lisbon, Portugal, is looking for 2 Postdocs to join our team at the Champalimaud Research Program.
The position
The Postdocs will work on a project in the research group of Dr. Klaas van Gisbergen in the Tissue Immunity Lab at the Champalimaud Foundation. The aim of the project is to understand how T cells differentiate in response to local cues in solid tumors to ultimately employ this knowledge for the development of immunotherapy for improved control of cancer. The postdocs will be working on independent, but related research projects and tasks will include the planning and design of experiments, supervision of co-workers, writing research manuscripts and presentation of the data at national and international conferences.
The project
This project has two separate research lines to improve our understanding of how T cells provide immune defense against cancer. 1. We aim to define the developmental paths of T cells during tumor outgrowth to understand where, when and how tumor-specific T cells differentiate into distinct lineages. Our analysis will identify how the potential of T cell precursors can be exploited in cancer immunotherapy to target tumor growth. 2. We will determine which environmental cues are important to instruct the differentiation and maintenance of T cell subsets in solid tumors. Understanding of these instructive cues will be important to steer T cell development for immunotherapeutic purposes. The research will be performed using state-of-the-art techniques in in vivo models, flow cytometry and transcriptional profiling.
The lab
The lab of Tissue Immunity focuses on the development of memory CD8 T cells in infection and tumor settings and the transcriptional and molecular pathways underlying CD8 T cell differentiation. The eventual goal is to improve employment of CD8 T cells for the purpose of cancer immunotherapy. The lab is embedded in the department of Cancer and Physiology at the Champalimaud Foundation that provides a lively, internationally oriented, scientific environment with excellent facilities. The research is strongly multidisciplinary and includes neuroscience, tumor biology and tumor immunology making use of state-of-the-art techniques in in vivo models, molecular biology, flow cytometry and fluorescence microscopy.
Your profile
We are looking for enthusiastic colleagues with a PhD in Biology / Biomedical Sciences, who are highly motivated and have a proven interest in immunology and oncology. The candidates are expected to take initiative and perform well in a team and preferably have hands-on experience with animal experimentation and multi-color flow cytometry and/or transcription profiling and bioinformatics analysis. The ability to present and publish the findings of the research is essential.
Department: Cancer and Physiology, Tissue Immunity (van Gisbergen) Lab
Website: https://www.fchampalimaud.org/research/groups/van-gisbergen
Number and type of fellowships or contracts to be awarded: 2 fellowship/s
Application start date: *As soon as possible
Application closing date: Open until filled
Expected position starting date: Sept 1st, 2024
Required Education Level: PhD
Skills/Qualifications
Minimum qualifications
PhD in Biomedical Sciences or related areas
Specific Requirements
Essential skills:
General skills include the ability to independently run a research project and tasks will include the planning, design and execution of experiments, supervision of co-workers, writing research manuscripts and presentation of the data at national and international conferences.
Required technical lab skills include in vivo mouse experimentation, flow cytometry analysis and in vitro culture work.
Desirable skills that will also be considered:
Molecular techniques and Bioinformatics.
Languages: English, Excellent
Benefits
Competitive remuneration package commensurate with skills, qualifications and experience;
Full immersion into a research excellence ecosystem with highly motivated researchers supported by state-of-the-art technology and continuous development opportunities;
- Salary range: 2212 - 2391 euro/month;
Maximum allowable duration of the contract including the respective renewals OR Initial duration: 48 months with possibility of renewal.
Eligibility criteria
National, Foreign or Stateless candidate(s) who hold a PhD degree in Life Science Areas or other related scientific areas and a scientific and professional curriculum that reveals a profile appropriate to the activity to be developed.
In case of PhD degrees awarded by foreign higher education institutions, the degree must comply with the provisions of Decree-Law No. 341/2007, of 12th of October, and all formalities established therein must be fulfilled by the deadline for application submission.
Selection process
Candidates will be screened to determine eligibility based on minimum qualifications listed in call. Candidates meeting minimum requirements will be scored according to the required application materials: CV 70% weighting, motivation letter 20%, interview 10% (in case of a tie).
If provided, and if shortlisted, candidates' referees may be contacted and may count towards evaluation.
When tied, top candidates will be interviewed (in person, or remotely). The result of the interview is then the sole evaluation criteria (basic documentation required). If no tie, holding of interviews at the discretion of the Evaluation Committee.
Application materials
CV and letter of motivation indicating 2 references (one single pdf document).
Proof of qualifications (certificates) may be required at a later date for the formalisation of the contract agreement. Degrees obtained abroad may need to be formally recognised in Portugal.
How to apply
Candidates must complete the standard application form and submit a single annexed PDF document containing the application materials stated in the call.
The call reference will be asked and not having may invalidate your submission. This call reference is: "2PD Van Gisbergen Jul2024"
Applications are also accepted in paper, sent or handed to the Fellows Support Office at the Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, Portugal.
Notification of results
All candidates will receive a receipt of acknowledgment within 7-10 business days. The highest scoring candidate will be notified by email or telephone. All other candidates will be notified solely by email of the final outcome of the recruitment process.
After being notified, candidates will have 10 working days to present a claim for redress by email (******). If no claim is received by the Champalimaud Foundation, the Evaluation Committee's decision will become definitive.
About Us
Research is at the heart of the Champalimaud Centre for the Unknown, a modern research and clinical facility situated on the waterfront in Lisbon, Portugal. The goal of Champalimaud Research (CR) is to perform world-leading fundamental and translational research. Current research work is focused on the fields of neuroscience, physiology and cancer. Champalimaud Research comprises a team of over 400 scientists from around the world. English is the official language of the Centre. Lisbon's sunny Atlantic Mediterranean climate, vibrant culture and high quality of life make this a great place to live and work.
Relevant Institutional Information
In line with our community guidelines and Equality, Diversity and Inclusion policy and Gender Equality Plan, no candidate may be privileged, favored, prejudiced or deprived of any right or excluded from any duty on the basis of age, sex, gender identity, sexual orientation, race/ethnicity, disability, chronic illness, language, nationality, territory of origin, family status (marital, pregnancy and maternity, having or not having dependents), socioeconomic situation, education, religion, political or ideological beliefs, trade union membership, or on any other grounds which are irrelevant to decision-making.
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